People that suffer from migraines understand both their severity and likelihood of reoccurrence. The exact cause of migraines and their associated pain is not well understood. A multitude of both genetic and hormonal activities likely play a role in their onset by producing high levels of the neurotransmitter serotonin and resulting in inflammation (1). Many times this onset can be detected by the sufferer and is often perceived even before other symptoms occur. This is referred to as aura.
A myriad of treatments are available to treat headaches; however, only a few treatments specifically target migraines. Most over-the-counter (OTC) medications have been found to be ineffective in the treatment of migraines. However, a few medications, including prescription based sumitriptan and valproic acid, have been found to effectively treat migraines in clinical trials (1). These medications specifically target serotonin receptors and inhibit overly high levels of serotonin. Nonetheless, many of these treatments are extremely expensive and often cost 20-25 dollars a pill. Valproic acid is a derivative of valerenic acid, the active compound in the plant Valeriana officinalis (2). This plant is also known more commonly as valerian root. Like valproic acid, valerenic acid has also been shown to similarly suppress the central nervous system by binding 5HT serotonin receptors (3,4). That is why our Migraine Mender at Elk Haven Herbals includes pure valerenic acid derived from Valeriana.
A few other novel compounds are also showing promise in effectively treating migraines. For example, both nicotinic acid and riboflavin alleviated pain in migraine sufferers in Class I trials (1). Melatonin, a compound produced naturally by the pineal gland and used as a sleep aid, also showed similar results when comparing both treatment and placebo groups (5).
There are few products on the market designed specifically to treat migraines. Those in existence are often prescription based and extremely expensive. At Elk Haven Herbals we’ve combined the newest and most promising compounds including valerenic acid, nicotinic acid, riboflavin, and melatonin into a single treatment option - Migraine Mender.
The treatment should be taken as a daily supplement to reduce the frequency and severity of migraine occurrence.
1. Holland S., S.D. Silberstein, F. Freitag, et al. (2012). “Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults : Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society”. Neurology 78; 1346-1353. s
2. Henry T.R. (2003). "The History of Valproate in Clinical Neuroscience". Psychopharmacology bulletin 37 (Suppl 2): 5–16
3. Hendriks H., Bos R., and Koster S.j. (1984) “Central Nervous depressant activity of valerenic acid” Planta Medica 51 (1): 28-31.
4. Dietz, B.; Mahady, G.; Pauli, G.; Farnsworth, N. (2005). "Valerian extract and valerenic acid are partial agonists of the 5-HT receptor in vitro". Molecular Brain Research 138 (2): 191–197
5. Gagnier, Joel J. (2001) “The Therapeutic Potential of Melatonin in Migraines and other Headache types”. Alternative Medicine Review 6 (4) 382-389.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.