Individuals who suffer from Fibromyalgia and Chronic Pain Syndrome (CPS) experience widespread pain that persists (1). Understanding and treating these ailments is both challenging and complex. The complexity of treatment lies in the unknown and likely multifaceted cause of Fibromyalgia and CPS. However, as in-depth study has progressed, some likely causes have been revealed.
In a number of cases, chronic and neuropathic pain may be the result of overactive nuerotransmitters (2). In fact, inhibiting such transmitters has been shown to decrease associated pain. For example, mirtazapine, pregabalin (Lyrica), and gabapentin (Neurontin) have all been shown to significantly reduce chronic neuropathic pain (3,4). Similarly, picamilon, a unique and complex B-vitamin compound functions by increasing the concentration of GABA, a molecule in the brain that inhibits the activity of nuerotransmitters (5,6,7). At Elk Haven Herbals our Nerve Numb-er addresses the over-activity facet of chronic neuropathic pain by including picamilon, a natural-based neurotransmitter inhibitor.
Chronic pain may also be the result of trauma or nerve damage (8). New research shows promise in the field of neuroregenerative medicine. The mushroom Hericium erinaceus, has been shown to regenerate damaged nerves with daily oral administration (9). This is likely due to its increase in nerve growth factors (10). Nerve Numb-er includes a concentrated extract of this mushroom.
Lastly, chronic pain may be aggravated by tissue inflammation. Powerful Non-steroidal anti-inflammatory drugs (NSAIDS) such as indomethacin are commonly used to treat pain as a result of inflammation. Natural alternatives for synthetic antinflammatories (NSAIDS) are rare but do exist. The plant genus Scrophularia contains NSAIDS such as Verbascosaponin A, which has been shown to be twice as effective as indomethacin for decreasing inflammation (11). Moreover, unlike synthetic NSAIDS which are known to cause peptic ulcers, no side effects are known for Scrophularia- likely due to it’s unique mechanism of action (12). A potent extract of Scrophularia is included in Elk Haven Herbal’s Nerve Numb-er.
Most individuals suffering with fibromyalgia and chronic pain syndrome have tried a countless number of treatment methods . Elk Haven Herbals provides another treatment that includes natural-based and plant derived compounds that have shown to be effective in treating one of many possible causes of these ailments. To be taken daily. One month supply.
1. Nicola L. Dennis, Michael Larkin and Stuart W. G. Derbyshire (2013) “A giant mess’ – making sense of complexity in the accounts of people with fibromyalgia”. British Journal of Health Psychology. 18, 763–781
2. Hawkins, RA (2013). "Fibromyalgia: A Clinical Update". Journal of the American Osteopathic Association 113 (9): 680–689
3. Moore, RA; Wiffen, PJ; Derry, S; McQuay, HJ (2011). "Gabapentin for chronic neuropathic pain and fibromyalgia in adults". In Moore, R Andrew. Cochrane database of systematic reviews (Online) (3): CD007938.
4. Nurcan, Üçeyler; Sommer, C; Walitt, B; Häuser, W "Anticonvulsants for fibromyalgia". Cochrane Database of Systematic Reviews (Online) (10): CD010782.
5. Matsuyama K, Yamashita C, Noda A, Goto S, Noda H, Ichimaru Y, Gomita Y (1984). "Evaluation of isonicotinoyl-gamma-aminobutyric acid (GABA) and nicotinoyl-GABA as pro-drugs of GABA". Chem. Pharm. Bull. 32 (10): 4089–95
6. Mirzoian RS, Gan'shina TS (1989). "[The new cerebrovascular preparation pikamilon]". Farmakologiia i toksikologiia (in Russian) 52 (1): 23–6
7. E. V. Topol'nik I and A. A. Shestaka I(1999) “Effect of Picamilon on Inhibitory Postsynaptic Responses of Cortical Neurons”. Neirofiziologiya/Neurophysiology,Vol. 31, No. l, pp. 80-82.
8. Staud, Roland (2011). "Peripheral pain mechanisms in chronic widespread pain". Best Practice & Research Clinical Rheumatology 25 (2): 155–64.
9. Kah-Hui Wong, Murali Naidu, Pamela David, Robiah Bakar, & Vikineswary Sabaratnam (2012) “Neuroregenerative Potential of Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Higher Basidiomycetes), in the Treatment of Peripheral Nerve Injury” nternational Journal of Medicinal Mushrooms, 14(5): 427–446
10. Mori, K.; Obara, Y.; Hirota, M.; Azumi, Y.; Kinugasa, S.; Inatomi, S.; Nakahata, N. (2008). "Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells". Biological & Pharmaceutical Bulletin 31 (9): 1727–1732
11. Giner RM, Villalba ML, Recio MC, Mñez S, Cerd-Nicols M, Ros J. (2000) “Anti-inflammatory glycoterpenoids from Scrophularia auriculata”, Eur J Pharmacol ;389(2-3):243-52.
12. Li YM, Han ZH, Jiang SH, Jiang Y, Yao SD, Zhu DY. (2000) “Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis” Hemsl. Acta Pharmacol Sin.;21(12):1125-8.
*Results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.